znt10 als kambe

Insulin processing (Homo sapiens) From WikiPathways. Other transporters, such as the newly identified ZnT9 and ZnT10, may also be involved but this is presently unknown. (Kambe T et al, 2002). In these cells, ZnT5 mediates the transport of zinc into secretory granules that contain insulin.

Dec 21, 2017 · In humans, mutations or even Single Nucleotide Polymorphisms (SNPs) in ZnT or Zip genes have been already associated to particular diseases (Fukada and Kambe, 2011; Kambe et al., 2015). For example, mutations in ZnT10 are responsible for hepatic cirrhosis that is accompanied with Parkinsonism or mutations in Zip4 triggers Acrodermatitis

Zinc (Zn) hyper-accumulates in breast tumors and malignant cell lines compared to normal mammary epithelium. The mechanisms responsible for Zn accumulation and the consequence of Zn dysregulation are poorly understood. Microarrays were performed to assess differences in the expression of Zn transporters and metallothioneins (MTs) in human breast tumors and breast cancer cell lines. Real

Lung cancer is the most frequently occurring cancer worldwide and the leading cause of cancer-related death in the US, representing almost 14% of all cancers diagnosed and approximately 28% of all cancer deaths [1–4].With a lack of reliable diagnostic markers at early stages of disease and ineffective therapies, the prognosis for lung cancer patients is poor.

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ZnT1, ZnT5 and ZnT9 mRNAs were detected by RT-PCR in both the secretory odontoblast cells and human dental pulp. ZnT2, ZnT3 and ZnT10 mRNAs were not detected, and ZnT4 mRNA was detected in secretory odontoblasts only, which may be indicative of a specilaised zinc efflux function during the active secteroy phase of tooth development.


Two new fluorescent sensors for Zn2+ that utilize fluorescein as a reporting group, Zinpyr-1 and Zinpyr-2, have been synthesized and characterized. Zinpyr-1 is prepared in one step via a Mannich reaction, and Zinpyr-2 is obtained in a multistep synthesis that utilizes 4‘,5‘-fluorescein dicarboxaldehyde as a key intermediate. Both Zinpyr sensors have excitation and emission wavelengths in

TRANSPORTERS FOR CELLULAR INCORPORATION OF Cd AND Mn IN MAMMALS. It has long been considered that metallothionein (MT), a cysteine-rich metal-binding protein, plays several crucial roles in the transport and accumulation of Cd in mammalian cells ().MT can efficiently bind Cd, as well as other metals such as Zn, Cu, Bi, Hg, and Ag, and protect against cytotoxicity of these metals.

Dec 12, 2012 · Zinc is an essential trace element that plays a vital role in maintaining many biological processes and cellular homeostasis. Dysfunctional zinc signaling is associated with a number of chronic disease states including cancer, cardiovascular disease, Alzheimer’s disease, and diabetes. Cellular homeostasis requires mechanisms that tightly control the uptake, storage, and distribution of zinc.


Takanori Iwasaki, Reiko Imanishi, Ryohei Shimizu, Hitoshi Kuniyasu, Jun Terao, and Nobuaki Kambe . Copper-Catalyzed Alkyl–Alkyl Cross-Coupling Reactions Using Hydrocarbon Additives: Efficiency of Catalyst and Roles of Additives. The Journal of Organic Chemistry 2014, 79 (18) , 8522-8532. DOI: 10.1021/jo501006u.

The soil-dwelling social amoeba Dictyostelium discoideum feeds on bacteria. Each meal is a potential infection because some bacteria have evolved mechanisms to resist predation. To survive such a hostile environment, D. discoideum has in turn evolved efficient antimicrobial responses that are intertwined with phagocytosis and autophagy, its nutrient acquisition pathways. The core machinery and

A genome-wide mapping study using male F2 zinc transporter 7-knockout mice (znt7-KO) and their wild type littermates in a mixed 129P1/ReJ (129P1) and C57BL/6J (B6) background identified a quantitative trait locus (QTL) on chromosome 7, which had a synergistic effect on body weight gain and fat deposit with the znt7-null mutation. The genetic segment for body weight on mouse chromosome 7 was


Dec 02, 2003 · However, the contribution of other zinc transporters expressed in brain, although likely to be minor (Huang, 1997; Huang et al., 2002; Kambe et al., 2002), cannot be ruled out yet. Nonetheless, our confocal microscopy immuno-localization studies in hippocampal neurons and the biochemical analysis of brain SV from wild-type and AP-3-deficient


Hemochromatosis is a frequent genetic disorder, characterized by the accumulation of excess iron across tissues. Mutations in the FPN1 gene, encoding a cell surface iron exporter [ferroportin (Fpn)], are responsible for hemochromatosis type 4, also known as ferroportin disease. Recently, Fpn has been implicated in the regulation of manganese (Mn), another essential nutrient required for

Oct 15, 2014 · Manganese (Mn) is an essential metal, but elevated cellular levels are toxic and may lead to the development of an irreversible parkinsonian-like syndrome that has no treatment. Mn-induced parkinsonism generally occurs as a result of exposure to elevated Mn levels in occupational or environmental settings. Additionally, patients with compromised liver function attributable to diseases,

Zinc is a metal that is essential for cell function as it plays important catalytic and structural roles in many proteins; however, excess zinc causes cell stress. Cadmium has similar chemical properties as zinc but is toxic and not required in biological systems. To maintain homeostasis, the levels of zinc detoxification genes are modulated through transcriptional regulation, which allows


ZIP1, ZIP3, ZIP6, ZIP12, and ZIP14 have been shown to have specific Zn influx activity [reviewed in Kambe et al. ], and the expression of all of these uptake transporter genes increased significantly with inflammation in our model . Conversely, we observed a marked reduction in the mRNA levels of the epithelial Zn uptake protein, ZIP4, and of

Als erste Frau in diesem Amt trat sie die Nachfolge von Peter Müller an, der diesen Verband zuvor 16 Jahre lang geführt hatte. Im Dezember 2017 hielten bei einer repräsentativen Forsa-Umfrage 45 % der CDU-Mitglieder Kramp-Karrenbauer für geeignet, Angela Merkels Nachfolgerin zu werden.

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外部発表論文リスト 外部発表履歴クエリ 安部 力 Abe, Chikara Abe, C., Tsuru, Y., Iwata, C., Ogihara, R. and Morita, H. Intravenous Infusion of Hyperosmotic NaCl Solution Induces Acute Cor Pulmonale in Anesthetized Rats


Many cancers are variably resistant to radiation treatment: some patients die within months, while others with the same tumour type and equivalent radiation protocol, survive for years. To determine why some tumours are radiosensitive, while others return after radiotherapy, requires new non-traditional appr

In MCF-7 cells, intracellular zinc ions accumulate in autophagosomes and are required for autophagosome-mediated tamoxifen-induced cell death [45]. The recent demonstration of the zinc transporters ZIP4, ZIP14, ZIP8, ZnT10, ZnT4, and ZnT2 in endosomes, lysosomes, and autolysosomes suggests that zinc is an essential contributor to autophagy [46,47].


Amongst mammalian ZnTs (with the exception of ZnT10, which has an asparagine instead of one of the two aspartates in the TMD and accordingly transports manganese in addition to zinc ), the zinc transport site and the overall structure of the TMD are highly conserved . The CTD, however, is much more variable and is thought to be critical in the

Author Summary Loss-of-function of the zinc transporter ZIP4 in the mouse intestine mimics the lethal human disease acrodermatitis enteropathica. This is a rare disease in humans that is not well understood. Our studies demonstrate the paramount importance of ZIP4 in the intestine in this disease and reveal that a root cause of lethality is disruption of the intestine stem cell niche and

1 transport and regulation of hepatic zinc by louis a. lichten a dissertation presented to the graduate school of the university of florida in partial fulfillment of the requirements for the degree of doctor of philosophy un iversity of florida 2009 page 2 2 2009 louis a. lichten page 3 3 to my mother and grandfather page 4


ALS is characterized by the degeneration of motor neurons, and mouse models show increased intracellular Cu levels and the formation of protein aggregates composed of SOD1 and Cu transport proteins such as Ctr1, CCS, Atox1, and Cox17 (344, 346). SOD1 aggregation has been associated with an alteration in protein stability, which is impacted by

锌在男性的睾丸、附睾和前列腺中都有分布, 参与保护睾丸Sertoli细胞、促进睾酮生成等过程;而锌转运体能精确调控各组织和生精细胞中锌的含量, 并在这些过程中发挥了重要作用。

So far, there are ten different mem bers have been found in mouse and human, named from ZnT1 ZnT10 ( 3 5) Due to the expression level and their responsiveness to the zinc status, the two members of Z nT family, ZnT1 and ZnT2, will be the major focus of this study. PAGE 26

Taetzsch T, Tenga M, Valdez G. Muscle Fibers Secrete FGFBP1 to Slow Degeneration of Neuromuscular Synapses during Aging and Progression of ALS. J Neurosci. 2017;37:70-82 pubmed 出版商 Hernandez Fleming M, Rohrbach E, Bashaw G. Sema-1a Reverse Signaling Promotes Midline Crossing in Response to Secreted Semaphorins.

2012年. Mita, M., Satoh, M., Shimada, A., Azuma, S., Himeno, S., Hara, S. (2012) Metallothionein deficiency exacerbates chronic inflammation associated with

Zn is the second most abundant metal in the human body, with 2–4 grams distributed throughout the whole body. Zn is generally taken in through food or breast milk, is absorbed via several intestinal Zn transporters, and is released into the bloodstream (Figure 1).Circulating Zn is taken up into cells and distributed within the cell (Figure 1).At each step, Zn transporters and

and ZnT10 were the latest members to be identified, and akin to ZnT1-7, share the same predicted structure of six transmembrane (TM)-spanning domains with cytoplasmic amino (N) and carboxy (C) terminals (see above cartoon), and contain a histidine-rich intracellular loop between TM IV and V which may act as the Zn2+binding region.

Golan Y, Itsumura N, Glaser F, Berman B, Kambe T, Assaraf Y. Molecular Basis of Transient Neonatal Zinc Deficiency: NOVEL ZnT2 MUTATIONS DISRUPTING ZINC BINDING AND PERMEATION. J Biol Chem. 2016;291:13546-59 pubmed publisher

Golan Y, Itsumura N, Glaser F, Berman B, Kambe T, Assaraf Y. Molecular Basis of Transient Neonatal Zinc Deficiency: NOVEL ZnT2 MUTATIONS DISRUPTING ZINC BINDING AND PERMEATION. J Biol Chem. 2016;291:13546-59 pubmed publisher

Dysfunctional zinc signaling is implicated in disease processes including cardiovascular disease, Alzheimer’s disease and diabetes. Of the twenty-four mammalian zinc transporters, ZIP7 has been identified as an important mediator of the ‘zinc wave’ and in cellular signaling. Utilizing siRNA targeting Zip7 mRNA we have identified that Zip7 regulates glucose metabolism in skeletal muscle

Jan 13, 2014 · ZIP5 and ZnT10 were not found in all 5 samples, whereas ZIP12, ZnT3 and ZIP2 were expressed in only 1‑2 out of 5 PBMC samples. Of note, stimulation by PHA led to an overall downregulation of zinc transporters in the PBMCs of 4 out of the 5 subjects.


(2014). Resveratrol–zinc combination for prostate cancer management. Cell Cycle: Vol. 13, No. 12, pp. 1867-1874.

1.1 Wilson disease. Wilson disease (hepatolenticular degeneration) is an inherited disorder that was first described by the neurologist Samuel Alexander Kinnier Wilson [].The clinical manifestations of this disorder result from an excessive accumulation of copper, first in the liver and then in the brain [].The disease has an autosomal recessive mode of inheritance with a prevalence of 1 in

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J 68)Kambe T, et al:Cloning and characterization of Biol Chem 280:30956, 2005 a novel mammalian zinc transporter, zinc 75)Fukunaka A, et al:Demonstration and transporter 5, abundantly expressed in pancreatic characterization of the heterodimerization of ZnT5 beta cells. J Biol Chem 277:19049, 2002 and ZnT6 in the early secretory

znt10. act aac tcc ttt cca ttc ccc. tat ccg cag cta ttg agc c. mrs2. cat acc caa cac tgc tga c. tta ccc cat ctt ttc cct cc. cacna1d. tgg tag gaa cag gtc cca ag. ggg aga agc aga ctc cac ag. glut1.

Louro B, Passos ALS, Souche EL, Tsigenopoulos C, Beck A, Lagnel J, Bonhomme F, Cancela L, Cerda J, Clark MS, Lubzens E, Magoulas A, Planas JV, Volckaert FAM, Reinhardt R, Canario AVM (2010) Gilthead sea bream (Sparus auratus) and European sea bass (Dicentrarchus labrax) expressed sequence tags: Characterization, tissuespecific expression and

dmt1 zip2 slc25a37 sfxn3 hfe slc6a20 kcnmb3 slc10a2 mrs2 slc24a1 slc33a1 znt10 slc12a2 slc6a8 aqp3 slc26a2 rhbg trpv1 tpcn1 gprc5a cacna1d cyb5a cyb561 tm4sf1 atp7b chrna1 kcnj8 prrg1 clcn2 slc6a4

Luis Olivares-Quiroz Olivares-Qu iroz Osbaldo Resendis-Antonio Editors Quantitative Models Quantitative for Microscopic to Macroscopic Macr oscopic Biological Biological Macromolecules Macr omolecules and Tissues

Dec 19, 2017 · Stability of ALS-related Superoxide Dismutase Protein variants. NASA Astrophysics Data System (ADS) Lusebrink, Daniel; Plotkin, Steven. Superoxide dismutase (SOD1) is a metal binding, homodimeric protein, whose misfolding is implicated in the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Monomerization is believed to be a key

JNUME Journal of Nutrition and Metabolism 2090-0732 2090-0724 Hindawi Publishing Corporation 173712 10.1155/2012/173712 173712 Review Article Zinc Transporters, Mechanisms of Action and Therapeutic Utility: Implications for Type 2 Diabetes Mellitus Journal of Nutrition and Metabolism 2090-0732 2090-0724 Hindawi Publishing Corporation 173712 10.1155/2012/173712

Human Health and Nutrition – New Research (2015).pdf – Free ebook download as PDF File (.pdf), Text File (.txt) or read book online for free.

We measured X-ray diffraction patterns at the GSECARS sector of the Advanced Photon Source (APS) and 12.2.2 sector of the Advanced Light Source (ALS). For the separate Pt-mixed samples, we have conducted in situ heating at the beamlines using near IR laser heating systems.


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@article{OkaT:2004, author = “Okada, T [et al.]”, title = “Crystallographic defects under surface morphological defects of 4H-SiC homoepitaxial films”, journal

Tomohiro Yamazaki Naoko Fujiwara Hiroko Yukinaga Miki Ebisuya Takuya Shiki Tomoya Kurihara Noriyuki Kioka Taiho Kambe Masaya Nagao Eisuke Nishida Seiji Masuda Mol Biol Cell 2010 Aug 23;21(16):2953-65.

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